吸烟,酒精和结肠癌的生存率受到免疫生物标志物的改变:一个人口代表性研究
Yasemin Adali1,2, Maurice B Loughrey1,3,4, Stephanie Craig3,5
1Centre for Public Health, Queen's University Belfast, School of Medicine, Dentistry and Biomedical Sciences, Belfast, United Kingdom.
吸烟会对结肠癌的存活率产生负面影响,特别是在免疫细胞透率较低的患者中. 吸烟对结肠癌 (CC) 存活率的影响受到瘤透免疫细胞密度的改变.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 吸烟和饮酒等生活方式因素是结肠癌 (CC) 预后的潜在决定因素.
- 这些因素与瘤透免疫生物标志物在CC生存中的相互作用仍然不完全理解.
研究的目的:
- 调查吸烟和酒精状态与CC特异性生存率之间的关联.
- 确定这些关联是否受到瘤透免疫细胞 (CD3+,CD4+,CD8+,FOXP3+) 密度的改变.
主要方法:
- 分析了661名接受手术的II或III期CC患者的基于人口的队列.
- 免疫组织化学 (IHC) 在瘤组织微阵列上进行,以量化免疫细胞密度.
- 考克斯的比例危险模型被用于评估CC特异性存活率,调整为混因素.
主要成果:
- 长期吸烟与CD3+,CD4+和FOXP3+免疫细胞密度较低的患者的CC特异性生存率较差有关.
- 在中部瘤中CD8+细胞密度较高的患者中,吸烟与更糟糕的结果有关.
- 不同免疫细胞密度小组的酒精消费和生存之间没有发现显著的关联.
结论:
- 吸烟与结肠癌存活率降低有关.
- 吸烟对CC存活率的影响受到瘤透免疫细胞密度的显著改变,这表明存在复杂的免疫媒介机制.
更多相关视频
13:04In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
相关概念视频
Cancer Survival Analysis
The Representativeness Heuristic
The Colonization of Land
Conservation of Small Populations
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
What is Population Genetics?
