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Updated: May 6, 2026

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对于亨廷顿病的认知措施的最小临床重要差异,使用功能作为

Cali M Roiboit1, Douglas R Langbehn2, Julie C Stout1

  • 1School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.

Movement disorders : official journal of the Movement Disorder Society
|February 3, 2026
PubMed
概括

亨廷顿病 (HD) 的认知测量最小临床重要差异 (MCID) 根据疾病阶段和时间而异. 使用功能能力可以帮助解释HD患者日常生活中的认知变化.

关键词:
亨廷顿的疾病是什么认知终点是指认知终点.有意义的变化是有意义的改变

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
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