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叙利亚仓鼠的MRI显示了SARS-CoV-2变种特定的神经炎症

Yisi Tang¹, Xiaohui Wei¹, Kai Gao¹

¹CAMS & PUMC, NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Science, National Human Diseases Animal Model Resource Center, National Center of Technology Innovation for Animal Model, State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China.

Microbiology spectrum

|February 3, 2026

概括

叙利亚仓鼠有效地模拟了SARS-CoV-2的大脑入侵,揭示了像XBB.1这样的免疫逃避变体会导致持久的嗅觉和海马体损伤. 这突显了由不断演变的变体带来的神经系统风险.

科学领域:

神经科学是一个神经科学.
病毒学病毒学
传染性疾病传染性疾病

背景情况:

SARS-CoV-2的神经表现影响30%-40%的患者,再感染增加了风险.
现有的动物模型对研究SARS-CoV-2神经侵入和变异特异性神经病变发生有局限性.

研究的目的:

建立和验证叙利亚仓鼠作为研究SARS-CoV-2变异特异性神经病变发生的优化动物模型.
为了比较不同SARS-CoV-2变体 (WH-09,XBB.1,BA.1,BF.7) 在初级感染和再感染后的神经侵入能力.

主要方法:

叙利亚仓鼠在初级感染和再感染期间感染了特定的SARS-CoV-2变种 (WH-09,XBB.1,BA.1,BF.7).
多模式磁共振成像 (MRI) 和组织病理学被用于评估神经解剖学变化.
为了验证模型,进行了MRI发现与组织病理学数据之间的相关性.

主要成果:

SARS-CoV-2 变种表现出差异性的神经侵入能力,主要感染和再感染之间存在显著差异.
免疫逃避变种 (XBB.1和WH-09) 导致了嗅觉-边缘区域的大量,持久的损伤,与低血有关.
其他变体 (BF.7,BA.1) 显示了最小的神经结构变化,表明神经病变减弱.

结论:

叙利亚仓鼠是研究SARS-CoV-2神经病变和变体演变的合适的神经解剖学优化模型.
哈姆斯特里的综合MRI和组织病理学有效量化神经损伤,突出了免疫逃避变体的威胁.
某些Omicron亚变体的减弱表型为开发针对SARS-CoV-2神经后续的病毒性修饰干预措施提供了洞察力.

关键词:

在SARS-CoV-2变种中.哈姆斯特哈姆斯特是一个子.组织病理学组织病理学神经成像是一种神经成像.神经炎症是一种神经炎症.

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