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Updated: Feb 5, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

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酸化酸Tau-pT181诱导了tau的聚合和认知功能障碍

Yong Luo1, Gang Wu1, Yi Liu1

  • 1Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of Alzheimer's disease : JAD
|February 3, 2026
PubMed
概括

陶蛋白在氨酸181 (p-Tau181) 的酸化直接导致陶聚合,导致突触损伤,认知障碍和阿尔茨海默病 (AD) 中的神经元损失. 这一发现支持p-Tau181作为阿尔茨海默病的关键诊断标志物和治疗点.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.的聚合是tau的聚合.塔乌-pT181 的时间.酸化的方法是:光化.

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