与瘤相关的巨细胞:瘤微环境的编排者
John B Echols1, Arthur W Meehan1, Kathleen A Marotto1
1Division of Molecular and Cellular Pathology, Department of Pathology and O'Neal Comprehensive Cancer Center, Heersink School of Medicine, The University of Alabama at Birmingham (UAB), Birmingham, AL.
American journal of physiology. Cell physiology
|February 3, 2026
概括
巨细胞,关键的免疫细胞,最初与瘤作斗争,但可以切换到促进癌症. 然后,与瘤相关的巨细胞 (TAMs) 在瘤微环境 (TME) 中驱动癌症的进展.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 巨细胞是重要的先天性免疫细胞,主导炎症,组织修复和伤口愈合.
- 癌症被视为一种慢性炎症状况,类似于无法愈合的伤口.
- 巨细胞最初通过消除包括瘤细胞在内的外来实体来表现出抗瘤特性.
研究的目的:
- 审查巨细胞在癌症中的多方面的作用.
- 阐明巨细胞转化为瘤相关巨细胞 (TAMs).
- 突出TAMs作为瘤微环境 (TME) 编排者的功能.
主要方法:
- 对炎症和癌症中的巨细胞生物学现有文献的综述.
- 细胞和分子机制驱动巨细胞两极化的分析.
- 检查TAMs对瘤进展的贡献.
主要成果:
- 巨细胞最初具有抗瘤能力,但在瘤内被重新编程.
- 瘤细胞和微环境因素诱导复极化成为前瘤TAMs.
- TAMs积极促进癌症的进展,并协调TME.
结论:
- 瘤抑制剂是癌症的核心参与者,从瘤抑制剂转变为促进剂.
- 了解TAM重编程对于开发新型癌症疗法至关重要.
- 瘤瘤显著影响瘤微环境,推动瘤的进展.
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