在ECHO队列中的空气污染暴露和出生体重
Whitney Cowell1, Hsiao-Hsien Leon Hsu2, Allan C Just3
1Departments of Pediatrics & Population Health, New York University Grossman School of Medicine, New York, New York.
JAMA network open
|February 3, 2026
概括
产前暴露于细颗粒物 (PM2.5) 与降低出生体重有关,在怀孕早期到中期有特定的敏感时期. 这些影响因婴儿的性别和地理区域而异,凸显了针对性减少暴露策略的需要.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 产周研究 产周研究
背景情况:
- 之前的研究表明,产前细颗粒物 (PM2.5) 暴露与出生体重之间存在负相关性.
- 在整个怀孕期间平均PM2.5暴露可能会掩盖发育期间敏感性的关键窗口.
研究的目的:
- 为了确定产前易受PM2.5暴露的特定窗口.
- 调查这些关联如何因婴儿的性别,种族/种族和地理区域而有所不同.
主要方法:
- 一个前性注册的美国队列的回顾性分析 (n=16,868个母婴对).
- 每日住宅PM2.5暴露估计使用机器学习模型,每周平均值计算每个怀孕周.
- 贝叶斯分布式滞后相互作用模型用于评估PM2.5和妊娠年龄 (BWGA) z分数的出生体重之间的特定星期关联.
主要成果:
- 总体而言,较高的PM2.5暴露与较低的BWGA z分数相关 (β=-0.06).
- 在怀孕早期 (1-5周) 确定了敏感性的一个关键窗口,特别是在男性身上.
- 观察到区域差异,东北,中西部和南部有负面关联和明显的关键窗口.
结论:
- 较高的PM2.5暴露与降低的BWGA z分数有关,怀孕早期到中期的临界窗口.
- 对PM2.5的敏感性因婴儿的性别和地理区域而异.
- 识别这些窗口对于理解生物机制至关重要,并为公共卫生干预提供信息,以减轻不利的出生结果.
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