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Updated: Feb 5, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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肝脏特异性抑制LPCAT3改善了与代谢功能障碍相关的脂肪性肝病

Vijay Kondreddy1, Ramchandra Reddy Jala2, Jhansi Magisetty3

  • 1Department of Biochemistry, Central University of Punjab, Bathinda, 151401, India. kvijay.reddy@cup.edu.in.

Journal of molecular medicine (Berlin, Germany)
|February 3, 2026
PubMed
概括

Lysophosphatidylcholine酸转移酶3 (LPCAT3) 通过增加酸 (AA) 和前列腺素E2 (PGE2) 促进肝脏脂质生成和与代谢功能障碍相关的脂肪性肝病 (MASLD). 用GalNAc-LPCAT3siRNA抑制LPCAT3为MASLD提供了一个潜在的治疗策略.

关键词:
阿拉基酸 是一种马斯尔德 马斯尔德是什么意思肝炎是一种肝炎.脂质生成是指脂肪的产生.代谢性疾病是代谢性疾病.siRNA疗法是指一种治疗方法.

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