美国非输血依赖性血病的经济负担
Arielle L Langer1, Amey Rane2, Keely S Gilroy2
1Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Journal of medical economics
|February 3, 2026
概括
与匹配的对照组相比,患有非输血依赖性沙拉西米亚 (NTDT) 的患者承担的医疗费用和资源利用率明显更高. 需要有效的治疗来减轻这种负担.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
背景情况:
- 非输血依赖性血病 (NTDT) 包括α和β血病,这些疾病需要仔细管理医疗保健资源利用率 (HCRU) 和相关成本.
- 了解NTDT的经济和利用负担对于开发有针对性的干预措施和改善患者结果至关重要.
研究的目的:
- 评估和比较所有原因的HCRU和阿尔法或β非输血依赖性沙拉西米亚 (NTDT) 患者与美国匹配的对照组之间的成本.
- 分析alpha-和beta-NTDT子组内的HCRU和成本差异.
主要方法:
- 来自Merative MarketScan商业/医疗保险数据库 (2013年1月1日 - 2021年6月30日) 的索赔数据的回顾性分析.
- 识别患有α或β-thalassemia的成年患者,根据输血频率和血红蛋白水平 (<10 g/dL) 定义NTDT.
- 根据年龄,性别,随访持续时间,实验室数据的可用性和支付者类型,将NTDT患者 (n=149) 与五个对照组 (n=745) 匹配;对至少12个月后的HCRU和成本进行评估.
主要成果:
- 与对照组 (p < 0.001) 相比,NTDT患者的住院病例率 (48.3%与16.5%) 和急诊室访问率 (61.1%与39.1%) 显著增加 (p < 0.001).
- 年度医疗保健费用在NTDT患者 (29,107 PPPY) 与对照组 (9,042 PPPY) 相比显著更高 (p < 0.001).
- 在α-和β-NTDT子组中观察到HCRU和成本增加的类似趋势.
结论:
- 与匹配的对照人群相比,在美国,患有NTDT,包括α和β-thalassemia的患者面临着显著更大的全因医疗资源利用率和成本负担.
- 这些发现突出了迫切需要有效的治疗策略,以减轻经济影响,并改善NTDT患者的临床结果.
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