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在患有I-IIIB阶段黑色素瘤的患者中进行术后疾病监测的纵向ctDNA监测
George Ansstas1, Karam Khaddour2, Sumedha Sudhaman3
1Washington University in St. Louis St. Louis, MO United States.
概括
术后循环瘤DNA (ctDNA) 检测是黑色素瘤复发的强有力的预后标志物. 这种血液测试显著预测了I-IIIB阶段黑色素瘤患者的无复发生存率.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 癌症生物标志物 癌症生物标志物
背景情况:
- 循环瘤DNA (ctDNA) 是癌症管理的新兴生物标志物.
- 早期发现复发和疾病监测在黑色素瘤治疗中至关重要.
研究的目的:
- 评估手术后ctDNA检测在I-IIIB阶段黑色素瘤患者中的预后价值.
- 评估ctDNA动态对临床决策的影响.
主要方法:
- 对190名患有I-IIIB阶段黑色素瘤患者的真实世界数据的回顾性分析.
- 使用个性化,瘤知情的16倍数mPCR-NGS测试来检测ctDNA.
- 与临床结果相关联的ctDNA结果,包括无复发生存率.
主要成果:
- 手术后ctDNA阳性与较短的无复发存活时间显著相关 (HR: 40.63,P<0.0001).
- 这种关联对于区域或远程复发 (HR:39.55,P<0.0001) 仍然显著.
- 在多变量分析中,ctDNA阳性是RFS最强的独立预后因素.
结论:
- 手术后ctDNA检测为黑色素瘤复发提供了显著的预后价值.
- 个性化ctDNA分析有助于对I-IIIB阶段黑色素瘤进行纵向疾病监测.
- ctDNA对临床决策的影响需要进一步调查患者的治疗结果.
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