哈普得分优于系统性炎症生物标志物,用于局部晚期直肠癌的预后
Peipei Shen1, Tiantian Yang2, Yawen Cong2
1Department of Radiotherapy and Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Biomolecules & biomedicine
|February 3, 2026
概括
血红蛋白-专蛋白-淋巴细胞-血小板 (HALP) 评分有效预测局部晚期直肠癌 (LARC) 患者的生存率. 低HALP表明结果更差,使其成为一个有价值的预后工具.
科学领域:
- 在瘤学瘤学.
- 临床生物标志物 临床生物标志物
- 癌症研究 癌症研究
背景情况:
- 局部晚期直肠癌 (LARC) 中系统性炎症和营养生物标志物的预后价值尚未确定.
- 确定可靠的生物标志物对于LARC治疗分层和患者管理至关重要.
研究的目的:
- 在LARC患者中全面评估12个基于炎症的指数的预后表现.
- 确定用于预测接受新辅助化疗和手术的LARC患者的整体生存期 (OS) 和无病生存期 (DFS) 的最有信息的生物标志物.
主要方法:
- 来自三家医疗中心的427名II-III期LARC患者 (2010-2021) 的回顾性分析.
- 对12个治疗前血源生物标志物的评估,包括血红蛋白-专蛋白-淋巴细胞-血小板 (HALP) 得分.
- 预测性能使用一致性指数 (C指数),接收器操作特征曲线 (时间AUC) 下的时间依赖区域和Brier分数进行评估.
主要成果:
- 血红蛋白-专蛋白-淋巴细胞-血小板 (HALP) 评分显示了OS和DFS的强大和一致的预后性能.
- 较低的HALP得分与更糟糕的OS和DFS有显著的关联.
- 多变量分析证实低HALP是较差的OS和DFS的独立风险因素.
结论:
- 血红蛋白 - 专蛋白 - 淋巴细胞 - 血小板 (HALP) 评分是一种简单,具有成本效益和可靠的生物标志物,用于LARC患者的预后分层.
- HALP可以帮助识别那些可能受益于加强治疗策略的高风险患者.
- 将HALP集成到名ograms中可以提高LARC的预后准确性.
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