降低的糖蛋白激素β-5与男性衰老和丸激素下降有关,导致脂肪增加
Gengmiao Xiao1, Aijun Qian2, Zhuo Gao3
1Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
The Journal of clinical investigation
|February 3, 2026
概括
糖蛋白激素β5 (GPHB5) 作为关键的中间体,将丸激素与男性的脂肪调节联系起来. 这种激素影响能量消耗,并对抗肥胖,解释了对脂肪的作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 分子生物学分子生物学
背景情况:
- 衰老导致或雌激素的降低,导致脂肪积累.
- 雌激素直接影响女性脂肪细胞,但丸激素在男性脂肪细胞代谢中的作用尚不清楚,这表明存在缺失环节.
研究的目的:
- 为了识别连接丸激素和脂肪调节的中间激素.
- 调查糖蛋白激素β5 (GPHB5) 作为这个缺失环节的作用.
主要方法:
- 与年龄和丸激素相关的临床GPHB5血液水平.
- 研究了对培养细胞和AR淘汰赛小鼠GPHB5表达的影响.
- 研究了GPHB5基因切除对小鼠脂肪组织和能量消耗的影响.
主要成果:
- 在男性中,GPHB5水平与年龄负相关,与丸激素正相关.
- 丸激素通过雄激素受体 (AR) 上调GPHB5的表达.
- 在雄性小鼠中,GPHB5 缺乏导致肥胖,减少能量消耗和白色脂肪组织色受损.
结论:
- GPHB5是"缺失"的中间激素,将丸激素与其对脂肪组织的代谢作用联系起来.
- 在男性中,GPHB5调解丸激素对能量消耗和肥胖的影响.
- GPHB5在调节男性身体脂肪积累和能量平衡方面发挥着至关重要的作用.
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