相关实验视频
Updated: Feb 5, 2026

06:51
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
5.8K
在患有胆管癌的患者中开发静脉血栓栓塞的风险评估模型
Piangrawee Niprapan1, Phichayut Phinyo2,3, Worakitti Lapisatepun4,5
1Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
概括
在胆道管癌 (CCA) 患者的静脉血栓栓塞 (VTE) 中开发了一种新的风险评估模型 (RAM). 该模型识别了较低风险的患者,有助于在CCA中预防VTE的临床决策.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 医学统计 医学统计
背景情况:
- 静脉血栓塞栓症 (VTE) 在胆管癌 (CCA) 患者中具有重大临床挑战.
- 对于VTE,现有的风险评估模型 (RAM) 对于CCA群体来说是不够的.
研究的目的:
- 开发和验证一种新的RAM,用于预测被诊断为CCA的患者的静脉瘤发病率.
- 确定与CCA患者VTE发展相关的关键临床预测因素.
主要方法:
- 这是一项追溯性研究,涉及694名新诊断的CCA患者,持续了五年.
- 后退消除的物流回归分析,以确定重要的预测因素.
- 开发和验证一个评分系统,评估歧视 (AuROC) 和负预测值 (NPV).
主要成果:
- 在12个月的随访期间,观察到VTE发病率为13.11%.
- 确定了五个关键预测因素:ECOG评分≥2,肝内CCA,IV期CCA,总 bilirubin≤13 mg/dL,和CA19-9>1600 U/mL.
- 开发的RAM显示了可接受的歧视 (AuROC 0.70) 和强大的NPV,特别有用于识别低风险患者.
结论:
- 已开发了一种经过验证的RAM,其中包含CCA患者VTE的五个关键风险因素.
- 该模型有助于临床医生识别具有较低VTE风险的CCA患者.
- 建议进行外部验证,以确认开发的RAM的概括性.
相关概念视频
Design Example: Analyzing Capacity Contours for Flood Risk Assessment
326
Flood risk assessment involves careful planning and analysis to ensure the safety of communities near water retention structures. Capacity contours are a vital tool in this process, as they illustrate the potential spread of water at specific levels in a given area. In the context of building a bund across a small valley, these contours play a critical role in evaluating the safety of nearby residential areas.In this example, the bund is intended to store stormwater in the valley. The engineers...
326
Venous Return
12.4K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.4K
Relative Risk
2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Venous Thrombosis I: Introduction
468
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
468
Factors Affecting the Risk of Infection
13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Nursing Process for Patient and Caregiver Teaching I: Assessment and Diagnosis
2.5K
The nursing process provides a clinical decision-making framework for patients and families to establish and implement a personalized care plan. Since part of the nurse's duties is to teach patients, the steps of the nursing process are the most effective way to approach instruction. The nursing process and the teaching-learning process are inextricably linked.
It is critical to determine the patient's learning needs during the assessment. Determination of learning needs compounds data...
It is critical to determine the patient's learning needs during the assessment. Determination of learning needs compounds data...
2.5K

