对脊椎动物生命史特征的控制显示,有效的种群大小不会影响突变率或基因组大小
Brooke Weinstein1, Scott William Roy1,2
1Department of Molecular and Cell Biology, University of California-Merced, Merced, CA 95343.
概括
实际种群大小 (Ne) 不会导致脊椎动物的突变率 (μ) 或基因组大小 (GS) 的变化. 生产时间,而不是Ne,介导了Ne和μ之间的关系,挑战了漂移有限进化理论.
科学领域:
- 进化遗传学 进化遗传学
- 进行比较基因组学.
- 人口遗传学 人口遗传学
背景情况:
- 跨物种的突变率 (μ) 和基因组大小 (GS) 的变化是进化遗传学的关键问题.
- 漂移障碍假设 (DBH) 和突变危险假设提出,有效种群大小 (Ne) 通过选择效率影响μ和GS,预测较小种群中的较高μ和较大的GS.
- 之前的一项研究报告了脊椎动物中Ne和μ之间的负相关性,支持了DBH.
研究的目的:
- 在脊椎动物中重新分析有效种群大小 (Ne),突变率 (μ) 和基因组大小 (GS) 之间的关系.
- 在因果框架内明确控制生命历史特征,以测试模型隐含的条件独立性.
- 通过重新评估Ne的解释能力来挑战漂移有限基因组进化的普遍性.
主要方法:
- 对55种脊椎动物物种 (哺乳动物,鸟类,爬行动物,鱼类) 的数据集进行了基因谱路径分析.
- 基因突变率 (μ) 估计来自高覆盖率的父子三组.
- 在一个因果框架内,对六个生命史特征进行明确控制,包括生长时间 (GT) 和交配系统.
主要成果:
- 之前报告的Ne和μ之间的负相关性完全由生成时间 (GT) 介导;一旦GT被考虑,Ne对μ没有可检测的影响.
- 在控制GT之后,交配系统成为μ的最强的预测因素.
- 基因组大小 (GS) 与Ne,μ或它们的相互作用无关,并且与构建μ的生命史共变脱.
结论:
- 有效种群大小 (Ne) 对脊椎动物突变率 (μ) 或基因组大小 (GS) 的变化具有最小的解释能力.
- 生产时间 (GT) 在介导Ne和μ之间的关系方面起着至关重要的作用.
- 这些发现挑战了广泛的假设,即Ne是通过漂移有限过程推动基因组进化的主要驱动力.
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