孕期大脑中二元形诱导神经毒性的单细胞解剖:代谢干扰和血脑屏障功能障碍
Tingting Zhang1, Zhou Qi2, Yunfei Teng3
1The Second Affiliated Xian Hospital of Xi'an Jiaotong University, Xi'an 710000, China.
Environmental science & technology
|February 3, 2026
概括
杀菌剂二甲型 (DMM) 暴露会改变怀孕小鼠的大脑细胞功能和新陈代谢,可能会影响孕产妇和胎儿的健康. 这种农药残留物在怀孕期间存在风险,影响神经发育和血脑屏障.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 发展性毒理学 发展性毒理学
背景情况:
- 在人类的带血液中检测到包括二甲型杀虫剂 (DMM) 在内的农药残留物,这引发了对胎儿暴露的担忧.
- 农药对孕妇和胎儿的神经毒性影响是一个关键的研究领域.
研究的目的:
- 在怀孕小鼠中研究杀菌剂DMM的神经毒性作用.
- 通过使用集成单细胞RNA测序和代谢分析来阐明DMM诱导的神经毒性的机制.
主要方法:
- 怀孕小鼠脑组织的单细胞RNA测序 (scRNA-seq).
- 脑组织的新陈代谢分析.
- 对细胞间通信网络的分析.
主要成果:
- 暴露于DMM会改变神经细胞群的比例和功能 (微细胞,寡细胞,星体细胞,内皮细胞).
- 观察到代谢重编程和血脑屏障 (BBB) 功能障碍.
- 确定了细胞特异的转录变化和异常的PI3K-AKT-mTOR信号传递.
- 检测到氨基酸,脂质和能量代谢的障碍.
- 在DMM暴露下观察到增强的病理信号网络.
结论:
- 在怀孕的小鼠中,DMM暴露会诱导显著的神经毒性和代谢障碍.
- 这些发现突出了怀孕期间接触农药对母亲和胎儿健康的潜在风险.
- 提供有关农药安全性评估和神经保护策略的见解.
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