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Updated: Feb 5, 2026

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
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Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

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结构-活动关系和新单菌体的晶体学研究

Vid Kavaš1, Carlos Contreras-Martel2, Stane Pajk1

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.

Journal of medicinal chemistry
|February 3, 2026
PubMed
概括

研究人员研究了与阿兹特雷诺姆相关的单菌药物,以改善抗菌活性. 新的衍生品显示出对抗抗性细菌的潜力,如金黄色葡萄球菌,其晶体结构显示出用于增强PBP抑制的新型结合相互作用.

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