一个机器学习模型用于预测慢性乙型肝炎患者的完整病毒学反应,这些患者接受一线核胺类同类疗法
Xiaoqin Yuan1, Xinyi Xiang1, Hongqian Xu1
1Department of Epidemiology, School of Public Health, Chongqing Medical University, Chongqing 400016, China.
概括
机器学习可以准确地预测慢性乙型肝炎 (CHB) 患者的完整病毒学反应 (CVR),这些患者接受核胺类类似物 (NA). 使用基线HBVDNA和HBeAg等因素的XGBoost模型实现了高预测性能.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 机器学习在医学中的应用
背景情况:
- 完整的病毒学反应 (CVR) 是慢性乙型肝炎 (CHB) 患者使用核胺类同类 (NA) 的首要治疗目标.
- 预测CVR对于优化CHB管理中的NA治疗策略至关重要.
研究的目的:
- 开发和验证一种机器学习 (ML) 模型,用于预测第一线NAs的CHB患者的CVR.
- 确定影响48周内CVR成就的关键预测因素.
主要方法:
- 对2394名CHB患者的回顾性分析,这些患者接受了第一线NAs治疗.
- 使用单变量分析,拉索,SVM-RFE和Boruta算法进行特征选择.
- 七个ML模型的开发和比较,使用SHapley添加式解释 (SHAP) 进行解释.
主要成果:
- XGBoost模型获得了最高的性能,其AUC为0.864 (训练) 和0.823 (验证).
- 显著的CVR预测因素包括基线HBVDNA,HBeAg状态,DBIL,年龄,肝硬化,ALT,PLT,FIB4和HBsAg.
- 基于Web的CVR预测计算器可在http://yuanxq.shinyapps.io/CVR-prediction-app.io上使用.
结论:
- 一个可解释的机器学习模型已成功开发和验证,以预测48周后的CVR.
- 该模型有助于预测一线NA治疗的CHB患者的治疗结果.
更多相关视频
相关概念视频
Modeling in Therapy
474
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
474
Simplified Synchronous Machine Model
785
The Synchronous Machine Model is a fundamental tool in analyzing and ensuring the transient stability of power systems. This model simplifies the representation of a synchronous machine under balanced three-phase positive-sequence conditions, assuming constant excitation and ignoring losses and saturation. The model is pivotal for understanding the behavior of synchronous generators connected to a power grid, particularly during transient events.
In this model, each generator is connected to a...
In this model, each generator is connected to a...
785
Wind Turbine Machine Models
608
In the growing field of wind energy, incorporating wind turbine models into transient stability analysis is essential. Induction and synchronous machines are the primary models used, with induction machines being prevalent due to their simplicity and reliability.
Induction machines interact through the rotating magnetic field generated by the stator and the rotor. The key parameter is slip, which is the difference between synchronous speed and rotor speed relative to synchronous speed. Slip is...
Induction machines interact through the rotating magnetic field generated by the stator and the rotor. The key parameter is slip, which is the difference between synchronous speed and rotor speed relative to synchronous speed. Slip is...
608
Machines
579
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
A free-body diagram of the...
579
Predicting Molecular Geometry
45.9K
VSEPR Theory for Determination of Electron Pair Geometries
45.9K
Receiver Operating Characteristic Plot
488
A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
488


