最近的手术前阿片类药物处方与微手术乳房重建后的并发症增加有关
Patricia M Fuentes1, Matthew Q Dao2, Emma Lascar1
1Division of Plastic and Reconstructive Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 10 Union Square East, Suite 2 L, New York, NY 10003, United States.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
|February 3, 2026
概括
在微手术乳房重建 (MBR) 中,术前使用阿片类药物与更高的并发症率和医疗保健使用量的增加有关. 这项研究强调阿片类药物是MBR患者的重要危险因素.
科学领域:
- 在瘤学瘤学.
- 整形外科 整形外科 整形外科
- 医疗保健服务研究 医疗服务研究
背景情况:
- 阿片类药物通常被处方给乳腺癌患者.
- 接受微手术乳房重建 (MBR) 的患者经常最近接触过阿片类药物.
- 手术前阿片类药物使用对MBR结果的影响尚不清楚.
研究的目的:
- 调查最近的阿片类药物暴露与术后并发症之间的关联.
- 评估手术前阿片类药物使用对MBR后医疗保健利用的影响.
主要方法:
- 使用TrinetX国家数据库 (2010-2025) 对接受MBR的成年女性患者进行回顾性队列分析.
- 倾向性得分匹配 (1:1) 来比较阿片类药物使用与非阿片类药物使用组.
- 主要结局包括30天后的并发症 (伤口脱皮,手术部位感染,败血症,尿路感染,PE);次要结局包括30天后的再入院,急救诊所和1年后的再手术.
主要成果:
- 服用阿片类药物组 (3780名患者) 的30天并发症发生率显著提高,包括伤口脱光 (RR 1.37),SSI (RR 1.35),败血症 (RR 1.59),尿道感染 (RR 2.04),PE (RR 2.24).
- 阿片类药物使用者体验到更大的医疗保健利用率,增加了再入院 (RR 1.25),急救诊所 (RR 1.57) 和重新手术 (RR 1.29).
结论:
- 最近的手术前阿片类药物使用是微手术乳房重建后早期和晚期并发症的重要风险因素.
- 研究结果表明,在接受MBR的患者的治疗中,需要考虑阿片类药物使用状态.
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