亚裔美国人和患有乳腺癌的白人患者生存率和相关特征的差异
Yongxin Li1, Dexiang Li2, Xinlong Tao2
1Clinical Medical College, Qinghai University, Xining, China; Breast Disease Diagnosis and Treatment Center, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China.
Clinical breast cancer
|February 3, 2026
概括
亚裔美国乳腺癌患者的生存率比白人患者更好. 这种生存优势在各种子组和调整关键因素后仍然存在,表明潜在的保护因素.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 健康差异 在健康上的差异
背景情况:
- 有限的研究比较了亚裔美国人和白人人口之间的乳腺癌存活率.
- 现有研究主要关注黑人与白人患者生存差异.
研究的目的:
- 为了比较亚裔美国人和白人患者之间的乳腺癌生存结果.
- 在调整了人口统计和临床因素后,以确定生存差异.
主要方法:
- 使用SEER数据 (2010-2021) 的回顾性队列研究.
- 倾向性得分匹配 (PSM) 以平衡基线特征.
- 卡普兰-梅尔曲线和考克斯模型用于生存分析 (整体生存率和乳腺癌特异性生存率).
主要成果:
- 该研究包括374,930名患者 (44,092名亚裔美国人,330,838名白人).
- 亚裔美国患者在PSM后的整体存活率 (HR=0.78) 和乳腺癌特异性存活率 (HR=0.88) 显著改善.
- 亚裔美国人的生存优势在调整预后因素后仍然显著 (OS HR=0.77,BCSS HR=0.86).
结论:
- 与白人患者相比,患有乳腺癌的亚裔美国患者的生存率高于白人患者.
- 这种生存益处在各个子组中是一致的,并且独立于关键预后因素.
- 亚裔美国人群体中潜在的内在生物学或生活方式保护因素需要进一步调查.
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