系统性炎症与金属植入体患者血清水平之间的关联:来自NHANES 2015-2020年的证据
Dingxiang Hu1, Jing Chen2, Jiajun Lin3
1Department of Rehabilitation Therapy, Jiangsu Second Rongjun Hospital (Jiangsu Rongjun Hospital), Wuxi, Jiangsu 214000, China.
概括
通过炎症负担指数 (IBI) 测量较高的炎症,与金属植入物患者的血清含量增加有关. 这种关联在男性和老年人中更强烈,这表明炎症会影响暴露.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学是生物材料的科学.
- 毒理学 毒理学 毒理学
背景情况:
- 金属假肢,特别是---合金 (CoCrMo),引起了人们对金属离子释放的担忧.
- 主体炎症状态可能会影响离子的释放,除了磨损和腐蚀.
- 炎症负担指数 (IBI),结合C反应蛋白和中性粒细胞与淋巴细胞比率 (NLR),是全身炎症的标志物.
研究的目的:
- 调查炎症负担指数 (IBI) 与血清和水平之间的关联.
- 根据性别和年龄,探索这种关联中的潜在差异.
主要方法:
- 与668名参与者进行NHANES数据 (2015-2020年) 的横截面分析.
- IBI计算为CRP (mg/L) ×NLR;分析了血清中的和水平.
- 使用调查加权线性回归模型来评估IBI和血清之间的关联,并进行子组分析.
主要成果:
- 较高的IBI与较高的血清含量显著相关;含量没有显示差异.
- 在IBI和血清之间发现了积极的相关性,特别是在男性和50-70岁的个人中.
- 在完全调整的模型中,最高IBI三位数显示9.978nmol/L的血清比最低三位数高 (P<0.001).
结论:
- 在金属植入物患者中,IBI和血清之间存在积极的关联,但不是.
- 这些发现表明系统性炎症和暴露之间存在联系,特别是在男性和老年人中.
- IBI可能有助于识别患有高水平风险的患者,这需要进一步的前性调查.
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