TiO2的抗菌活性,细菌粘附和表面形态纳米颗粒涂层的正牙弹性体:一个体外研究研究
Saleh M Baqandwan1, Nehal F Albelasy1, Waleed Eldars2
1Department of Orthodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
International orthodontics
|February 3, 2026
概括
ортодонтика带上的二氧化纳米颗粒 (TiO2 NPs) 涂层显示出显著的短期抗菌活性和减少的细菌粘附. 然而,随着时间的推移,疗效会减弱,这凸显了改善涂层耐久性的必要性,以获得持续的临床益处.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 矯正牙科 矯正牙科是一種矯正牙科.
背景情况:
- ортодонтическое治疗涉及的设备,可以庇护细菌,导致并发症.
- 弹性体结合剂容易产生细菌粘附和生物膜的形成.
- 二氧化纳米颗粒 (TiO2NP) 具有潜在的抗菌特性.
研究的目的:
- 为了评估TiO2NP涂层正牙带的抗菌活性.
- 为了评估细菌粘附和表面形态的变化随着时间的推移.
- 为了确定不同TiO2NP度 (5%和10%) 对结合性质的影响.
主要方法:
- 通过热水方法合成的TiO2NP,并使用sol-gel浸泡涂层应用于带.
- 使用阿加扩散试验对Streptococcus mutans进行了抗菌活性测试.
- 在人工唾液中浸泡后,用殖民地形成单位 (CFU) 量化的细菌粘附.
- 使用扫描电子显微镜 (SEM) 分析了表面形态和粗度.
主要成果:
- 与对照组相比,5%和10%的TiO2 NP涂层显著增加了抗菌活性,并减少了细菌粘附 (P<0.001).
- 10% TiO2 NP 组表现出最强的效果,细菌粘附率降低了多达 9933 CFU.
- 抗微生物药物的有效性在4周内下降,抑制区的显着减少.
- SEM显示了表面粗度增加,特别是在10%的涂层下.
结论:
- TiO2 NP涂层,特别是10%的TiO2 NP涂层,为正义带提供短期的抗菌益处.
- 涂层在唾液中的降解会降低长期有效性.
- 由于纳米颗粒度较高而增加的表面粗度可能会影响生物膜抗性.
- 为了持续的临床应用,需要进一步优化纳米粒子分散和涂层耐用性.
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