用-90树脂微球进行放射栓塞的可行性,无需测量肝脏内胆固醇瘤的肺间隔分离率
Myungsu Lee1, Do Hoon Kim1, Minseok Suh2
1Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Korean journal of radiology
|February 3, 2026
概括
精简的放射栓塞使用-90树脂微球,没有肺分离率 (LSF) 评估是可行的肝脏内胆固醇癌 (ICC). 这种方法为符合条件的ICC患者提供了传统方法的实际替代方案.
科学领域:
- 干预性放射学 干预性放射学
- 肝胆瘤学 肝胆瘤学
- 核医学就是核医学.
背景情况:
- 肝脏内胆管癌 (ICC) 是一种具有挑战性的肝癌.
- 传统的放射性栓塞需要肺间隔分数 (LSF) 评估,增加了复杂性和时间.
- 简化治疗方案对于改善患者获取和效率至关重要.
研究的目的:
- 评估在没有先前LSF测量的情况下在ICC患者中使用90树脂微球进行放射性栓塞的可行性.
- 评估这种简化方法的安全性和有效性.
- 为了确定这种方法是否可以成为标准协议的实际替代方案.
主要方法:
- 在没有LSF评估的情况下,对23名ICC患者接受90树脂微球治疗的回顾性分析.
- 资格标准包括瘤大小<10厘米和缺乏特定的血管侵袭.
- 使用剂量计模型规定了辐射活性,假设5%的LSF和瘤与正常 (TN) 的比率为3.
- 治疗后的伊-90PET/CT剂量测量在一小部分患者中进行.
主要成果:
- 管理的中位数活性为1.43 GBq.
- 瘤吸收剂量 (TAD) 的中位数为339 Gy (假设) 和371 Gy (PET/CT).
- 没有出现症状的辐射肺炎. 客观反应率包括52%的部分反应和48%的稳定疾病.
- 两年局部瘤无进展生存率为81.1%.
结论:
- 精简的放射性栓塞,没有LSF评估是可行的选择的ICC患者.
- 这种方法简化了工作流程,并可能为传统方法提供一种切实可行的替代方案.
- 进一步的研究可以在更大的队列中验证这些发现.
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