关于Hericium erinaceus多糖的代谢学研究,在小鼠中干预乙醇诱导的胃潰瘍中进行
Xin Gao1, Wenxu Wang2, Jinlong Zhang2
1College of Food Science and Engineering, Changchun University, Changchun, 130022, Jilin, China; College of Food Science and Nutrition Engineering, Jilin Agricultural Science and Technology College, Jilin, 132101, China.
International journal of biological macromolecules
|February 3, 2026
概括
的多糖 (HEP) 显示出对小鼠的乙醇诱导的胃的胃保护作用. 代谢分析显示,HEP调节关键的代谢途径,改善氧化应激,炎症和粘膜修复.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢学 代谢学 代谢学
- 胃肠病学 胃肠病学
背景情况:
- 的多糖 (HEP) 已经证明了潜在的胃保护性质.
- 乙醇诱导的胃是研究治疗的常见模型.
- 了解与胃和HEP干预相关的代谢变化至关重要.
研究的目的:
- 评估HEP对小鼠在乙醇诱导的胃的保护作用.
- 用非向代谢学来描述HEP干预引起的血清代谢变化.
- 确定由HEP调节的特定代谢途径,有助于胃保护.
主要方法:
- 在老鼠中以乙醇诱导的胃模型.
- 在胃内给药Hericium erinaceus多糖 (HEP).
- 评估胃的严重程度,生化指标和血清代谢物通过非目标代谢学.
主要成果:
- HEP的使用显著降低了胃的严重程度,并调节了粘膜屏障完整性和亡通路.
- HEP干预调节了血清氧化应激和炎症标志物.
- 非向的代谢组在接受HEP治疗的小鼠中发现了单碳代谢,氨酸和甲氨酸代谢,尼古丁酸盐和尼古丁胺胺代谢,以及甘氨酸脂代谢的改变.
结论:
- 的多糖 (HEP) 对乙醇诱导的胃有显著的胃保护作用.
- HEP干预调节特定的代谢途径,有助于减少氧化应激,炎症和增强胃粘膜修复.
- 这项研究为HEP治疗胃的治疗机制提供了新的代谢学见解.
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