短暂的急性神经元激活反应是由大脑脊髓液中高度的寡核酸引起的

Mariana Bravo-Hernandez1, Curt Mazur1, Hao Chen1

  • 1Ionis Pharmaceuticals, Inc., Carlsbad, CA 92008, United States.

Nucleic acids research
|February 3, 2026
PubMed
概括

在临床前模型中,高剂量内寡核酸 (ON) 输送可能会导致急性神经元激活. 这种反应与阴离子化有关,可以通过在ON配方中补充来缓解.

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