格林和MBOAT4在Serpentes中丢失了
Rui Resende Pinto1,2, Raquel Ruivo1, Josefin Stiller3
1CIMAR/CIIMAR- Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Porto, Portugal.
Open biology
|February 3, 2026
概括
饥饿激素格林 (GHRL) 和其激活酶MBOAT4在蛇,黑猩猩和头中分别失去了. 爬行动物的这种损失可能反映了对更低能耗和更长的禁食期的适应.
科学领域:
- 进化生物学是进化的生物学.
- 进行比较的基因组学.
- 生理适应生理适应.
背景情况:
- 代谢和能量平衡对于生物的生存和适应至关重要.
- 基因网络进化为不同血统的生理变化提供了洞察力.
- 格雷林 (GHRL) 是一种关键的激素,调节食欲,食物摄入量和体重.
研究的目的:
- 为了研究爬行动物的 ghrelin (GHRL) 激素系统的进化轨迹.
- 为了识别特定的爬行动物系,其中GHRL信号已经丢失.
- 为了将GHRL的损失与代谢和生理适应相关联.
主要方法:
- 在Squamata,Testudines,Crocodilia和Rynchocephalia中对112种爬行动物的基因组分析.
- 鉴定GHRL基因存在/不存在以及MBOAT4基因完整性.
- 对基因丢失事件和生理特征的比较分析.
主要成果:
- 在蛇 (32个物种),黑 (4个物种) 和头 (2个物种) 中观察到GHRL基因的独立损失.
- 激林激活酶MBOAT4的基因也在这些相同的基因系中被侵蚀.
- 失去GHRL/MBOAT4系统与代谢转变相关,包括减少静止能量消耗.
结论:
- 林信号通路在爬行动物中已经独立失去了多次.
- 这种损失与减少能源消耗和长时间禁食能力的适应有关.
- 进化压力塑造了这些爬行动物群体的能量代谢和荷尔蒙调节.
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