孕产妇糖尿病和子女风险 在后代
Bénédicte Driollet1, Asma M Ahmed2, Jennifer A Hutcheon3
1Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Quebec, Canada.
Pediatrics
|February 3, 2026
概括
孕产妇糖尿病,包括1型,2型和孕期糖尿病,与儿童风险更高有关. 产前暴露可能在这种增加的风险中起作用.
科学领域:
- 围产期健康 围产期健康
- 神经发育障碍 神经发育障碍
- 内分泌学 在内分泌学.
背景情况:
- 有限且不一致的证据存在于母亲糖尿病和后代神经发育障碍,特别是.
- 以前的研究往往无法区分糖尿病亚型 (T1DM,T2DM,GDM),这些亚型都有独特的原因.
- 这项研究调查了母亲糖尿病亚型和儿童之间的特定关联.
研究的目的:
- 确定1型糖尿病 (T1DM),2型糖尿病 (T2DM) 和妊娠糖尿病 (GDM) 与后代风险之间的关联.
- 为了区分与每个糖尿病亚型相关的风险.
- 探索母亲糖尿病对儿童神经发育结果的影响.
主要方法:
- 加拿大安大略省的一项回顾性出生队列研究包括了2002年至2018年间的活产儿.
- 孕产妇和儿童的健康记录与2020年3月之前的糖尿病暴露和诊断相关.
- 考克斯的比例危险模型被用来估计的调整危险比率 (aHR),用定量偏差分析来评估稳定性.
主要成果:
- 该研究分析了超过210万名儿童,其中7.6%暴露于孕产妇糖尿病 (T1DM,T2DM或GDM).
- 母亲糖尿病暴露与所有亚型的风险增加有关:T2DM (aHR 1.40),T1DM (aHR 1.32) 和GDM (aHR 1.14).
- 母亲T1DM或T2DM的更长时间与更高的风险相关,这些发现在偏差分析中一致.
结论:
- 孕产妇糖尿病,特别是T1DM和T2DM,与后代风险增加有显著的关联.
- 虽然更长的疾病持续时间显示出趋势,但它并没有显著放大风险.
- 产前代谢和由母亲糖尿病引起的炎症因素可能与儿童的发病有关.
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