区分各种具有明显细胞质特征的脏细胞瘤,旧和新,基于它们不同的脏管状起源
Kevin J Zhang1, Jason M Hafron2, Catherine Xie3
1Department of Medical Oncology and Therapeutic Research, City of Hope Chicago, Zion, IL, USA Kezhang@CIH.org.
Annals of clinical and laboratory science
|February 3, 2026
概括
本综述详细介绍了具有清晰细胞质的质的差异化,包括清晰细胞细胞癌 (ccRCC) 和其他变体. 准确的病理诊断对于有效的患者管理和理解不同的生物行为至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 清细胞细胞癌 (ccRCC) 是一种常见的脏瘤,因脂质含量而具有清晰细胞质的特征.
- ccRCC的转移潜力很高,需要准确的诊断.
- 几种新发现的质共享明显的细胞质特征,使差异诊断复杂化.
研究的目的:
- 提供全面的病理路线图,以区分具有明显细胞质特征的质群体.
- 讨论这些脏瘤变体的临床结果和管理策略.
主要方法:
- 综述各种细胞癌亚型的病理特征.
- 清细胞瘤之间的形态相似性和差异的比较分析.
- 关于临床结果和清晰细胞质的质群的治疗的文献综述.
主要成果:
- 确定了几种具有清晰细胞质的脏瘤实体,包括带有纤维性肌瘤 (FMS) 的RCC,清晰细胞 papillary脏细胞瘤 (CCP-RCT),具有低恶性瘤潜力的多局部囊性脏细胞瘤 (MCRCNLMP) 和eosinophilic真空瘤 (EVT).
- 强调染色恐惧性细胞癌 (Ch-RCC) 和转位性细胞癌 (tRCC) 也表现出明显的细胞质特征.
- 强调了由于形态相似性的诊断挑战,以及基于不同生物行为的差异化的重要性.
结论:
- 精确的病理差异化质群体与清晰的细胞质是必要的.
- 了解这些变异的独特生物行为指导临床管理.
- 本综述是病理学家和临床医生管理这些复杂脏瘤的指南.
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