血清克洛托水平变化的临床含义在2型糖尿病中,具有差异性的C-模式
相关实验视频
Updated: Feb 5, 2026

10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
26.5K
Xiaohong Luo1, Dongqing Zhang2, Xuexuan Zhang2
1Department of Vitreoretinal Surgery, Shantou Balder Eye Hospital, Shantou, Guangdong, China.
Annals of clinical and laboratory science
|February 3, 2026
概括
血清Klotho水平在2型糖尿病 (T2DM) 中较低,与胰岛素抵抗 (IR) 相反相关. 克洛托有效地区分T2DM患者与健康个体的C-水平不同.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 生物化学 生物化学
背景情况:
- 克洛托与葡萄糖和脂质代谢有关,可能会影响胰岛素抵抗 (IR),这是2型糖尿病 (T2DM) 的关键特征.
- 了解克洛托在T2DM中的作用,特别是关于不同的C-模式,对于代谢健康研究至关重要.
研究的目的:
- 为了调查T2DM患者血清Klotho水平的变化.
- 检查T2DM中不同C-水平的血清Klotho和胰岛素抵抗 (IR) 之间的关系.
- 评估Klotho在区分T2DM亚组中的诊断性能.
主要方法:
- 在690名T2DM受试者和对照者中测量了血清克洛托,禁食血葡萄糖 (FPG),糖化血红蛋白 (HbA1c),C-和禁食胰岛素 (FINS).
- 计算了对胰岛素抵抗的恒温模型评估 (HOMA-IR).
- 采用接收器操作特征 (ROC) 分析来评估诊断能力.
主要成果:
- 在T2DM患者中,血清Klotho水平显著降低,在超C血症组进一步下降.
- 克洛托与HOMA-IR,FINS,FPG和HbA1c有显著的反相关性,特别是在T2DM中具有高C血症.
- 克洛托在区分T2DM患者与对照患者不同的C-模式方面表现出良好的能力.
结论:
- 在T2DM中,血清Klotho水平与胰岛素抵抗 (IR) 有负相关性.
- 克洛托作为一个有价值的生物标志物,用于区分T2DM患者与健康个体不同的C-模式.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
5.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
Diabetes Mellitus: Overview and Type I Subtype
5.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.4K
Differential Leveling
718
Differential leveling is a precise method in surveying used to determine the elevation difference between two points. Its primary goal is to establish accurate vertical measurements to create level surfaces or grade lines critical for designing and constructing infrastructures such as roads, bridges, and buildings.The procedure for differential leveling begins with setting up and leveling the instrument at a point where the benchmark can be seen. The level rod is held on the benchmark (BM), and...
718
Peptide Bonds
83.1K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.1K
Types of Hormones
83.6K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.6K
Alterations in Respiration II
1.8K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.8K

