[州建德的食谱通过调节Th17/Treg免疫平衡,改善了大肠发病的老鼠]
Binjie Li1,2, Xiaofang Zhou2, Xiaomeng Lang3
1Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
概括
州吉杜食谱 (XZJD) 治疗通过减少炎症和恢复免疫平衡,改善了大肠 (UC) 在老鼠中的治疗. 它调节了Th17/Treg细胞和关键蛋白质表达,减轻了结肠粘膜损伤.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性结肠炎 (UC) 是一种具有复杂免疫失调的慢性炎症性肠病.
- Th17/Treg细胞平衡在维持肠道免疫平衡方面发挥着至关重要的作用.
- 确定针对免疫路径的新型治疗策略对于UC管理至关重要.
研究的目的:
- 在性结肠炎 (UC) 的老鼠模型中研究Xiezhuo Jiedu Recipe (XZJD) 的治疗机制.
- 评估XZJD对UC大鼠结肠粘膜炎症和免疫细胞概况的影响.
主要方法:
- 患有诱导UC的SD大鼠接受了XZJD,梅沙胺或盐水的不同剂量治疗.
- 结肠病理通过HE染色来评估.
- 用ELISA和免疫组织化学测量IL-6,IL-10和IL-17的血清和组织水平.
- 分析了奥克卢丁,ZO-1,ROR-γt和Foxp3的表达,以及Th17和Treg细胞的百分比,使用免疫光学,流细胞计,RT-PCR和西部斑点.
主要成果:
- 在UC大鼠中,结肠粘膜损伤显著,IL-6和IL-17升高,IL-10降低.
- 治疗XZJD显著降低了炎症标志物,并逆转了结肠中的病理变化.
- XZJD调节了Th17/Treg细胞平衡,增加Treg和减少Th17细胞,同时使ROR-γt和Foxp3表达正常化.
结论:
- 在大鼠模型中,XZJD在性结肠炎 (UC) 中显示出显著的治疗潜力.
- 该机制涉及缓解结肠粘膜炎症和恢复Th17/Treg免疫平衡.
- 通过调节关键的免疫路径,XZJD可能是管理UC的有希望的治疗剂.
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