提克障碍的神经成像
Yulia Worbe1, Bassam Al-Fatly2
1Paris Brain Institute (ICM), Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Movement Investigation and Therapeutics Team, Paris, France; Department of Clinical Neurophysiology, Sorbonne University, APHP-Sorbonne University - Hospital Saint-Antoine, Paris, France.
Handbook of clinical neurology
|February 3, 2026
概括
吉尔·德拉图雷特综合征 (GTS) 是一种神经发育网络障碍. 神经成像揭示了GTS中大脑结构和功能的改变,影响了运动和认知网络,为治疗提供了目标.
科学领域:
- 神经成像是一种神经成像.
- 神经发育障碍 神经发育障碍
- 网络神经科学 网络神经科学
背景情况:
- 吉尔·德拉图雷特综合征 (GTS) 越来越多地被视为神经发育网络障碍.
- 了解GTS的神经支需要合成各种神经成像发现.
研究的目的:
- 在GTS中综合了二十年的神经成像发现.
- 在整个生命周期中确定GTS中一致的神经解剖学和功能网络变化.
- 建立GTS研究和治疗的翻译框架.
主要方法:
- 对结构性MRI研究的审查 (VBM,皮质厚度,白质量测量).
- 扩散张力成像 (DTI) 和曲谱学数据的分析.
- 综合功能性MRI (fMRI) 关于网络动态的发现.
- 整合病变网络映射和基于坐标的网络映射.
主要成果:
- 不同质的灰色物质体积变化和运动/前额区域持续的皮质稀释.
- 改变了前-上和半球间通路中的白质完整性.
- 有证据表明,皮质-状-状-甲状腺-皮质和大脑-皮质电路受损.
- 在不同的方法论中,在一个共同的tic-associated网络上发现了趋同的结果.
结论:
- 在多个网络中,GTS涉及大脑结构和功能的广泛变化.
- 神经成像为了解GTS病理生理学和开发有针对性的干预提供了一个框架.
- 网络生物标志物的识别有望指导神经调节和治疗策略.
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