相关实验视频
Updated: Feb 5, 2026

06:24
Establishing 3D Endometrial Organoids from the Mouse Uterus
Published on: January 6, 2023
7.7K
子宫内膜微生物组对在接受ART的妇女中引起炎症的不孕症的贡献
F Giangrazi1, J A Sugrue1,2, V M Sularea1
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Human reproduction (Oxford, England)
|February 3, 2026
概括
接受辅助生殖技术 (ART) 的女性未能怀孕,其子宫内膜微生物组发生了变化,有益乳酸菌减少. 代谢物丁酸盐与增加的微生物多样性有关,损害子宫内膜功能并增加炎症,阻碍胚胎植入.
科学领域:
- 生殖科学 生殖科学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 子宫内膜微生物组的变化与生育问题有关,但机制尚不清楚.
- 微生物代谢物调节粘膜表面的免疫和屏障功能.
- 子宫内膜微生物代谢物对生育能力的影响尚未被探索.
研究的目的:
- 研究经历ART失败的女性子宫内膜微生物组的变化.
- 为了确定微生物代谢物是否影响子宫内膜细胞机制,这对于胚胎植入至关重要.
主要方法:
- 在29名女性中对ART结果进行了前性纵向研究,这些女性患有无法解释的不孕症.
- 通过16S测序和RNA测序进行子宫内膜微生物组和转录组学分析.
- 在体外模型中使用子宫内膜细胞系和初级细胞来研究代谢物效应.
主要成果:
- 有ART衰竭的女性显示出较低的Lactobacillus spp. 和更高的致病性细菌 (Prevotella spp.,Corynebacterium spp. 这种类型的细菌). ) 的情况.
- 更高的多样性和特定的致病细菌与负面的ART结果相关.
- 丁酸盐暴露损害了表皮屏障功能,增加了炎症标志物,并在体外影响了受体/决定化标志物.
结论:
- 在没有ART的妇女中,子宫内膜微生物组发生了改变,其特点是乳酸菌减少和多样性增加.
- 代谢物丁酸盐对子宫内膜上皮质屏障功能产生负面影响,并促进炎症.
- 研究结果表明,微生物失生症和丁酸盐有助于ART后的植入失败.
关键词:
在16S测序过程中,辅助生殖 辅助生殖是一种辅助生殖.在子宫内膜上皮细胞.宫内膜的受体性 宫内膜的受体性这是子宫内膜的内分泌物.女性不孕症女性不孕症这是一种炎症炎症炎症炎症.微生物组是一个微生物组.无法解释的不孕不育.更多相关视频
相关概念视频
Infertility in Males
571
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
571
Infertility in Females
4.9K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
4.9K
Inflammation
62.1K
Overview
62.1K
Binet's Contribution to Measures of Intelligence
1.7K
Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
1.7K
Wechsler's Contribution to Measures of Intelligence
2.1K
David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
2.1K
Receptor-mediated Endocytosis
111.0K
Overview
111.0K

