风险管理和进一步使用已知致病变异的捐赠者的性子
Dorian Accoe1, Guido Pennings2, Sandra Janssens3,4
1Bioethics Institute Ghent, Department of Philosophy and Moral Science, Ghent University, Ghent, Belgium Dorian.Accoe@UGent.be.
Journal of medical ethics
|February 3, 2026
概括
对于自身相对衰退性疾病的捐赠性雌同体的使用是可以接受的. 如果遗传风险与一般人群风险相比,继续使用是一种选择,确保生育诊所政策的一致性.
科学领域:
- 生殖医学 生殖医学
- 人类遗传学 人类遗传学
- 生物伦理学生物伦理学
背景情况:
- 在捐赠者怀孕的个体中,自体相衰退性遗传疾病可能会发生.
- 尽管复发风险较低,但生育诊所有时会在发现病原性变异后限制供体雌同体的使用.
研究的目的:
- 倡导关于使用来自携带病原体变异的捐赠者的雌同体的一致政策,用于自身复发性病症.
- 解决与捐赠者怀孕有关的伦理考虑和风险评估.
主要方法:
- 政策分析和道德审查.
- 在捐赠者受孕中对自身遗传的风险评估.
主要成果:
- 由于复发风险较低,对捐赠性子细胞的明确限制可能并不总是合理的.
- 考虑严重程度和个人偏好的个性化风险评估至关重要.
结论:
- 如果确定的遗传风险与一般人群风险相比,则可以接受继续使用捐赠性子细胞.
- 为了保持一致的实践,必须为生育诊所制定明确的原则性指导.
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