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Updated: Feb 5, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
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一个时间敏感的可塑性区分了胺酸的快速和持续的突触作用与其 (2R,6R) -hydroxynorketamine代谢物

Kyle A Brown1, Patrick J Morris2, Craig J Thomas2,3

  • 1Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

The Journal of neuroscience : the official journal of the Society for Neuroscience
|February 3, 2026
PubMed
概括

代谢物 (2R,6R) - 基诺基胺 (2R6R),而不是胺本身,在小鼠海马中驱动快速的可塑性和持续的转塑性. 这些效应由哺乳动物目标的拉巴素 (mTOR) 依赖信号传递介导,并涉及多个下游通路.

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