灵活的,可伸缩的,芯片上的光学子用于高通量生物颗粒操纵
Ziyi He1, Jianyun Xiong1, Yang Shi1
1Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, College of Physics & Optoelectronic Engineering, Jinan University, Guangzhou, China.
Light, science & applications
|February 3, 2026
概括
研究人员开发了灵活的,可伸缩的芯片上光学子 (FSOT),用于高通量操纵生物颗粒. 这项技术可以在复杂的生物环境中精确控制和分析细胞和病原体.
科学领域:
- 生物光子学 生物光子学
- 纳米技术纳米技术
- 微流体学 微流体学
背景情况:
- 传统的光学子在吞吐量,功能和适应性方面存在局限性,用于在动态生物环境中对芯片上的生物颗粒操纵.
- 单个致病生物颗粒的高通量捕获和操纵对于体外诊断和药物查至关重要.
研究的目的:
- 开发灵活和可伸缩的芯片上光学子 (FSOT) 用于在复杂的生物微环境中进行高通量生物颗粒操纵.
- 为了能够精确地控制和分析生物颗粒,包括病原体和细胞,在柔性和曲的生物基质上.
主要方法:
- 使用大规模,有序组装的微镜头制造FSOT,利用光子纳米喷射效应.
- 展示从亚-100 nm到几十微米的生物颗粒 (外体,细菌,哺乳动物细胞) 的高通量捕获,分类和调制.
- 评估FSOT的灵活性,可变形性和伸展性,以操纵曲的生物基质,并控制细胞间距离.
主要成果:
- 从高达1000个微镜头,FSOT使用光子纳米喷射效应使单个生物颗粒的高通量捕获和分类成为可能.
- 该系统在复杂和曲的生物微环境中展示了对生物颗粒操纵的高度灵活性.
- 通过控制细胞间距离,FSOT的伸展性允许实时调制和监测致病细菌和巨细胞之间的相互作用.
结论:
- FSOT代表了一种新型的芯片上光学子,具有高度的灵活性和伸展性,用于先进的生物颗粒操纵.
- 这项技术对生物颗粒的高通量动态分析和揭示细胞间相互作用具有重大前景.
- FSOT提供了一个强大的集成平台,用于精确的药物查和了解宿主-病原体动态.
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