通过时间变化大脑网络分析进行行为和精神疾病的神经认知表征
Xiao Chang1,2,3,4,5, Tianye Jia6,7,8,9,10, Zening Fu11
1Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, China. xchang@fudan.edu.cn.
Nature communications
|February 3, 2026
概括
动态大脑连接,或功能网络连接 (FNC),在任务期间的变化. 时间变化的FNC比静态连接更好地解释行为和精神病理,为认知提供了更深入的见解.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 脑部成像 脑部成像
背景情况:
- 人类的认知依赖于随着时间的推移大脑区域之间的动态相互作用.
- 传统的神经成像方法往往无法捕捉这些时间动态.
- 了解时间变化的功能网络连接 (FNC) 对于将大脑活动与认知和行为联系起来至关重要.
研究的目的:
- 在认知任务期间调查FNC的动态变化.
- 评估时间变化的FNC与任务执行和精神病理学有关的行为相关性.
- 探索认知任务如何重新配置大脑连接模式.
主要方法:
- 利用功能磁共振成像 (fMRI) 数据的滑动窗分析来捕捉时间FNC波动.
- 相关的时间变化的FNC测量与任务绩效指标.
- 与心理病理症状相关的动态FNC模式.
主要成果:
- 确定了持久的全脑FNC状态,这些状态随任务刺激而波动.
- 证明了区域FNC模式对特定任务条件有区别.
- 发现随时间变化的FNC解释了与静态连接相比,精神病理症状的变异比例更大.
结论:
- 认知任务可以动态地重塑区域和全脑连接.
- 时间变化的FNC提供了更全面的认知过程和行为的神经表征.
- 动态FNC状态提供了更细致的理解与认知和精神病理学有关的大脑功能.
相关概念视频
Higher Mental Functions of the Brain: Language
3.8K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
3.8K
Higher Mental Functions of Brain: Learning and Memory
2.1K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.1K
Classification of Illness
8.7K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.7K
Factors Affecting Illness
5.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
5.3K
Gradually Varying Flow
443
Gradually varying flow (GVF) in open channels describes situations where water depth changes slowly along the channel due to factors like non-uniform bed slope, channel shape variations, or obstructions. This flow type occurs when the depth adjusts gradually to balance gravitational forces, shear forces, and energy requirements, resulting in a low rate of depth change.Characteristics of Gradually Varying FlowGVF is commonly observed in natural streams, rivers, and canals, where flow depth...
443
Rapidly Varying Flow
500
Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...
500


