炎症因素对不稳定性胸痛风险的影响,从基因层面来看
Jie Lou1, QianZhen Huang1, Runfeng Zhan2,3
1of Clinical Laboratory, Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, No.140 renminnan road, Taicang, Jiangsu Province, China.
Scientific reports
|February 3, 2026
概括
炎症性细胞因子基因的遗传变异与中国人口的不稳定性心肌痛 (UA) 风险有关. 在IL-1β和TNF-α基因中的特定多态性与增加UA易受性和更高的炎症反应有关.
科学领域:
- 遗传学和分子生物学
- 心血管疾病研究研究
- 免疫学 免疫学 免疫学
背景情况:
- 炎症及其遗传调节在不稳定的心痛 (UA) 中至关重要,这是冠状动脉疾病 (CAD) 的表现.
- 影响UA细胞因子产生和炎症反应的遗传因素,特别是在中国人群中,需要进一步阐明.
研究的目的:
- 调查炎症性细胞因子基因多态,血清细胞因子水平和中国队列中不稳定性心痛风险之间的关联.
- 为了确定冠状动脉不稳定的潜在遗传生物标志物.
主要方法:
- 一项基于医院的病例控制研究,涉及160名UA患者和280名健康对照.
- 使用ELISA对血清细胞因子 (IL-1β,IL-6,IL-10,IL-17,IFN-γ,TNF-α) 的量化.
- 使用聚合酶链反应-限制片段长度多态 (PCR-RFLP) 和通过多变量逻辑回归进行关联分析,对13种细胞因子基因位点的基因定型.
主要成果:
- 与对照组相比,UA患者的所有测量细胞因子的血清水平显著升高 (p < 0.01),IL-10显示增加了3.2倍.
- 七个细胞因子基因位点的多态性,包括IL-1β-511 C/T和TNF-α-308 G/A,与UA敏感性显著相关 (p <0.05).
- 对IL-1β-511 C/T (AUC=0.87) 和TNF-α-308 G/A (AUC=0.84) 多态形态的ROC分析显示出强大的区分能力,灵敏度和特异性>80%.
结论:
- 特定的炎症性细胞因子基因多态,特别是IL-1β-511 C/T和TNF-α-308 G/A,与中国人群中UA风险增加和炎症反应加剧有关.
- 这些多态可能作为冠状动脉不稳定的潜在遗传生物标志物,需要进一步验证临床应用.
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