夜间限制的食通过肠道微生物群衍生的KYNA恒常性来破坏小鼠的精子生成
Donghui Yang1,2, Dong Xie1,2, Chuan Li1,2
1Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Communications biology
|February 3, 2026
概括
夜间限制性养 (NRF) 通过改变肠道微生物群和增加氨酸 (KYNA) 来降低男性生育能力和精子质量. 日间限制性养 (DRF) 不会影响男性生殖健康.
科学领域:
- 生殖生物学 生殖生物学
- 代谢的恒常状态 (metabolic homeostasis) 是指代谢过程中的恒常状态.
- 循环节律 循环节律 循环节律
背景情况:
- 时间限制养 (TRF) 通过昼夜节律影响代谢平衡.
- 对于TRF对男性生育能力和肠-丸轴的具体影响尚不清楚.
研究的目的:
- 研究不同TRF时间表 (白天与夜间) 对丸功能和精子生成的影响.
- 探索肠-丸轴和相关代谢物在TRF诱导的生殖变化中的作用.
主要方法:
- 给小鼠分配了夜间限制养 (NRF),白天限制养 (DRF) 或随意养.
- 评估丸指数,精子质量,并进行组织学分析.
- 分析了肠道微生物群组成 (16S rRNA测序) 和血清代谢学,重点关注像金酸 (KYNA) 这样的托代谢产物.
主要成果:
- NRF显著降低了丸指数和精子质量,精子细胞和精子数量减少.
- DRF没有对男性生殖参数产生不良影响.
- NRF改变了肠道微生物群和高氨酸 (KYNA) 水平.
- 外源KYNA的使用模仿了NRF对精子生成的负面影响.
结论:
- 食时间极大地影响男性生殖健康.
- 肠道衍生代谢物,如金酸 (KYNA),可能会调解夜间限制食对男性生育能力的不良影响.
- 这些发现表明男性生殖功能障碍的潜在治疗点.
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