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Updated: Feb 5, 2026

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
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Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

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DGCR8调节了转录合核酸切除修复的多个过程

Takaaki Watanabe1, Daiyu Yoshinami1,2, Hiroyuki Yamasaki1

  • 1Department of Molecular Life Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan.

Scientific reports
|February 3, 2026
PubMed
概括

在紫外线辐射后,DGCR8通过与转录合核酸切除修复 (TC-NER) 因素相互作用来协调DNA修复. 这种可能通过酸化调节的相互作用揭示了DGCR8的存在.

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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