在新生儿重症监护病房中,氧化物的患病率和安全性
Lucas C Collins1, Katherine B Daniel1, Veeral N Tolia2
1Duke University School of Medicine, Durham, NC, USA.
概括
对于婴儿持续性高胰岛素血糖低血糖症,Diazoxide的使用在NICU中稳定. 虽然有些婴儿需要额外的治疗,如利尿剂,但大多数婴儿在出院前停止服用氧化物.
科学领域:
- 新生儿科学 新生儿科学
- 儿科药理学 儿科药理学
- 内分泌学 在内分泌学.
背景情况:
- 氧化物是新生儿持续高胰岛素血糖低血糖症的关键治疗方法.
- 最近的研究表明,氧化的潜在不良影响和多样化的临床应用.
- 在新生儿重症监护室 (NICU) 描述二氧化的使用对于了解其现实世界的影响至关重要.
研究的目的:
- 描述在NICU中用氧化物治疗的婴儿的人口和临床特征.
- 分析二氧化的使用模式和相关疗法.
- 评估不同NICU中二氧化使用的变异性.
主要方法:
- 一项队列研究分析了2017年至2022年间345个NICU的数据.
- 纳入标准:怀孕24-41周之间出生的婴儿.
- 收集的数据包括氧化物暴露,低血糖诊断,不良事件和额外的治疗,比较暴露与未暴露的婴儿.
主要成果:
- 在545,065名婴儿中,22%患有低血糖症;0.16%接受过氧化.
- 氧化物利用率保持一致,在NICU之间存在显著的变化 (0-16%).
- 在暴露于氧化的婴儿中,有13%的婴儿开始尿液治疗,10%需要新的氧气支持,3%需要机械通风.
结论:
- 在NICU中使用氧化物显示在研究期间稳定的趋势.
- 虽然一些婴儿需要辅助疗法,如利尿剂,但大多数婴儿在出院前成功戒除了氧化.
- 进一步的研究可能会探索优化氧化治疗以尽量减少不良事件和额外的资源利用.
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