智能CaCO3涂层益生菌通过增强肠道机动性和调节微生物酶来缓解便秘,在洛佩拉胺诱导的老鼠模型中
Su-Nam Jeong1, Myoung-Jin Kim2,3
1Department of Environmental Engineering, Korea Maritime and Ocean University, Busan, 49112, Korea.
Scientific reports
|February 3, 2026
概括
一种新的碳酸涂层有效地将益生菌输送到肠道,改善大鼠的便秘症状. 这种用碳酸 (PEC) 系统封装的益生菌通过调节微生物酶和减少炎症来改善肠道健康.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 生物材料科学 生物材料科学
背景情况:
- 便秘是一种常见的胃肠道疾病,与肠道运动不良和肠道失调有关.
- 传统的益生菌面临着胃生存和向性肠道释放的挑战,限制了它们的有效性.
研究的目的:
- 开发和评估一种新的智能输送平台,即用碳酸 (PEC) 封装的益生菌,用于针对性地通过肠道输送益生菌.
- 评估PEC在洛佩拉胺诱导的便秘老鼠模型中的疗效.
主要方法:
- 五种益生菌菌株被封装在单层碳酸涂层中,创建了PEC系统.
- 该PEC系统是为pH和酸盐反应释放而设计的.
- 治疗疗效在患有洛佩拉胺诱导便秘的老鼠中被测试,剂量为15,50和150毫克/公斤.
主要成果:
- 以剂量取决的方式,PEC的使用显著改善了排便频率,便水分和肠道过渡速率.
- PEC选择性调节有害的肠道微生物酶 (β-葡萄糖酶,酸还原酶),同时节省有益的酶 (β-葡萄糖酶).
- 观察到减少全身炎症标志物 (TNF-α,IL-1β) 的趋势,高剂量PEC恢复参数到正常水平.
结论:
- 该PEC平台展示了作为下一代益生菌输送系统的潜力,克服了传统益生菌的局限性.
- 在治疗便秘和相关的胃肠道疾病方面,PEC显得有前途,在功能性食品和治疗中具有潜在的应用.
- 需要进一步的研究来分离碳酸封装的具体贡献.
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