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Updated: Feb 5, 2026

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
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The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat

Published on: June 17, 2016

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通过正反调节循环,TGFBI通过重塑益菌微环境来促进肝纤维化

Heming Wu1, Xueqian Yan1, Lijun Kuang1

  • 1Department of Basic Medical Sciences, School of Medicine, Xiamen University, Xiamen, China.

Communications biology
|February 3, 2026
PubMed
概括

转化生长因子β诱导蛋白 (TGFBI) 通过激活肝星细胞并促进巨细胞分化,驱动肝纤维化. 降低TGFBI水平为肝纤维化提供了潜在的治疗策略.

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相关概念视频

Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
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Feedback Loops01:01

Feedback Loops

In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
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Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
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Root Loci for Positive-Feedback Systems01:23

Root Loci for Positive-Feedback Systems

The Hartley oscillator is a positive feedback system that sustains oscillations by feeding the output back to the input in phase, thereby reinforcing the signal. Positive feedback systems can be viewed as negative feedback systems with inverted feedback signals. In these systems, the root locus encompasses all points on the s-plane where the angle of the system transfer function equals 360 degrees.
The construction rules for the root locus in positive feedback systems are similar to those in...
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