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双向动脉管的工程开发,为心肺绕道提供外围接入
Joel D Graham1, Thomas J Roussel2, Steven C Koenig2,3
1Department of Bioengineering, University of Louisville, Louisville, KY, USA. joel.graham@louisville.edu.
Cardiovascular engineering and technology
|February 3, 2026
概括
一种用于心肺绕道 (CPB) 的新型柔性尖端动脉管显示出有前途的双向流动能力. 这种设计旨在减少手术复杂性和在具有挑战性的心脏手术中的不良事件.
科学领域:
- 生物医学工程 生物医学工程
- 心血管外科心血管外科
- 医疗器械设计 医疗器械设计
背景情况:
- 心肺绕道 (CPB) 在心脏手术中对于血液管理至关重要.
- 周围管用于复杂的病例,但可以阻碍远端流动.
- 标准管可能需要移植,增加手术时间.
研究的目的:
- 评估一种新的灵活尖端动脉管,以实现双向流动.
- 评估外围CPB应用中的压力损失和流量分布.
- 改善具有挑战性的心脏外科手术程序的结果.
主要方法:
- 开发了一种具有双向流动的灵活尖端的22Fr管.
- 利用实验的全因数设计来测试16个尖端设计.
- 使用灵活树脂3D打印制造的原型.
主要成果:
- 最佳设计实现了4L/分钟双向流量,压力损失为74mmHg.
- 设计中的平均压力损失为87mmHg,每分钟4L.
- 主要出口流量平均为81%,尖端宽度和出口形状是关键因素.
结论:
- 新管设计是可行的,证明了与商业选择相比的双向流动.
- 为了临床开发,计划进行进一步的验证 (CFD,临床前测试).
- 目标是低成本,双向管,以提高外围CPB的安全性和效率.
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