晚期发病对多发性硬化症表型和结果的影响:来自多国注册表的证据
Amira Souissi1,2, Francesco Patti3, Tim Spelman4,5
1Neurology Department, LR18SP03 and Clinical Investigation Center Neurosciences and Mental Health, university hospital center Razi-Mannouba, Tunis, Tunisia.
Journal of neurology
|February 3, 2026
概括
晚期发病的多发性硬化症 (MS) 和非常晚期发病的MS与成人发病的MS相比,表现出更具侵略性的疾病进展和更高的残疾.理解这些差异对于管理所有年龄组的MS至关重要.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 临床研究 临床研究
背景情况:
- 多发性硬化症 (MS) 的严重程度在患者之间有很大差异.
- 疾病发病时的年龄是影响MS临床特征和残疾的关键因素.
- 描述晚发性MS (LOMS) 和非常晚发性MS (vLOMS) 对于量身定制的患者管理至关重要.
研究的目的:
- 为了比较晚发性MS (LOMS) 和非常晚发性MS (vLOMS) 与成人发性MS (AOMS) 的临床特征和残疾结果.
- 根据MS发病时的年龄来确定疾病进展和残疾里程碑的差异.
主要方法:
- 使用MSBase注册表进行的观察研究.
- 患者分为成人发病的MS (AOMS,18-39岁),LOMS (50-59岁) 和vLOMS (≥60岁) 的患者.
- 通过24周确认残疾进展,EDSS里程碑,SPMS转换和PIRA事件评估疾病进展,使用考克斯回归和PS-IPTW进行分析.
主要成果:
- 在81,236名患者中,LOMS和vLOMS分别占5.2%和1%.
- 初级渐进性MS在LOMS (21.7%) 和vLOMS (24%) 中更为普遍.
- LOMS和vLOMS患者表现出明显增加的残疾进展风险,EDSS 4和6里程碑,SPMS转换和第一个PIRA事件.
结论:
- 晚发性MS (LOMS) 和非常晚发性MS (vLOMS) 与更渐进的疾病过程有关.
- 与成人发性MS (AOMS) 患者相比,LOMS和vLOMS患者的残疾里程碑较高.
- 这些发现凸显了对特定年龄段的多发性硬化症管理策略的需要.
相关概念视频
The Evidence for Evolution
48.3K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.3K
National Nursing Organizations I
3.1K
Nursing organizations assume a significant role in consistently developing the nursing profession through education, research studies, establishing practice standards, and reforming health policies. Typically, nursing organizations operate at the regional, national, and international levels. For example, the International Council of Nurses (ICN) represents more than 28 million nurses worldwide. In contrast, the American Nurses Association (ANA) is a membership organization representing nurses...
3.1K
National Nursing Organizations II
2.1K
Nursing organizations play a vital role in representing nurses working in specialized clinical settings, such as the American Association of Critical-Care Nurses (AACN).
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
2.1K
Multiple Allele Traits
38.1K
The Concept of Multiple Allelism
38.1K
Predicting Reaction Outcomes
10.9K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.9K
Outcomes of Glycolysis
107.3K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.3K


