鼻腔殖民的频谱:糖尿病患者的频率和耐药性模式与非糖尿病人口的频率和耐药性模式
Maryam Rabeh1, Samaneh Shahrokh2, Mojtaba Akbari3
1Department of Microbiology, Faculty of Biological Sciences and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran.
BMC microbiology
|February 3, 2026
概括
糖尿病患者表现出更高的甲基西林耐药黄金葡萄球菌 (MRSA) 的鼻腔殖民率. 这凸显了在不同人群中监测MRSA的必要性,以制定有效的感染控制策略.
科学领域:
- 微生物学 微生物学
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
背景情况:
- 鼻腔是细菌的储存库,糖尿病患者更容易感染机会性感染.
- 糖尿病患者的免疫力受损和植物变化增加了他们对细菌殖民的风险.
研究的目的:
- 在糖尿病和非糖尿病患者中调查金黄色葡萄球菌和肠杆菌菌的鼻腔殖民.
- 评估细菌分离物中的抗生素耐药性,生物膜生成和耐药性基因.
主要方法:
- 一项涉及150名糖尿病人和150名非糖尿病人的横截面研究.
- 对抗生素耐药性和生物膜形成的表型评估.
- 使用PCR检测特定耐药基因 (mecA,blaCTX,blaSHV,blaTEM) 的基因型分析.
主要成果:
- 糖尿病患者中黄金葡萄球菌殖民率较高 (18.7%对12.7%),MRSA显著增加 (8%对1.3%).
- 两组之间多药耐药黄金菌 (MDR S. aureus) 没有显著差异.
- 糖尿病患者的肠杆菌菌殖民率较低 (3.3%对7.3%);尽管缺乏表型ESBL生产,但耐药基因普遍存在.
结论:
- 鼻腔MRSA殖民在糖尿病患者中更为普遍.
- 对MRSA鼻腔殖民的持续监测对于制定预防和治疗相关感染的策略至关重要.
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