整合深度学习和放射学,以精确识别动态对比增强MRI的光线A/B乳腺癌亚型
Jianfeng Shangguan1, Elena Shchukina2, Dimitar Monov3
1Radiology Department, Puyang Oilfield General Hospital, Puyang, China. jshangguan@castcn.org.
概括
一个新的混合成像模型使用动态对比增强MRI (DCE-MRI) 功能准确地区分乳腺癌亚型 (光线A/B). 这种非侵入性方法显示出高精度,可能减少了活检的需要.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 人工智能的人工智能
背景情况:
- 准确的乳腺癌亚型分类 (光线A与B) 对于治疗选择至关重要.
- 目前的方法依赖于侵入性活检和免疫组织化学 (IHC).
- 迫切需要用于可靠的亚型分类的非侵入性成像方法.
研究的目的:
- 开发和验证使用DCE-MRI的放射学和深度学习特征的混合分类模型.
- 要区分入侵性乳腺癌的光线A和B亚型.
主要方法:
- 开发了一种混合模型,将DCE-MRI的放射学和深度学习功能结合起来.
- 使用PyRadiomics提取了放射性特征,使用3D ResNet-50 CNN使用深度特征.
- 三种模型 (放射学,深度学习,混合) 使用测试和外部验证队列的AUC,灵敏度和特异性进行了比较.
主要成果:
- 混合型号实现了高性能:AUC 0.921,敏感度为88.6%,测试组的特异性为89.7%.
- 外部验证证实了强大的性能 (AUC 0.903).
- 形状和纹理的放射性特征,以及高层次的深度特征,是主要的贡献者.
结论:
- 混合方法为乳腺癌亚型分类提供了一种临床适用的非侵入性方法.
- 这种方法可以补充或部分取代活检,提高诊断准确度.
- 未来的研究包括对精确瘤学的基因组/临床数据进行前性验证和整合.
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