从甜菜糖到酸:发酵和下游过程的整体发展
Luca Antonia Grebe1, Christina Maria Krekel2, Constantin Alexander Maaß1
1AVT.BioVT-Biochemical Engineering, RWTH Aachen University, Forckenbeckstraße 51, 52074, Aachen, Germany.
Biotechnology for biofuels and bioproducts
|February 4, 2026
概括
本研究介绍了一种新的,具有成本效益的工艺,用于从甜菜糖蜜中生产酸,实现高产量和纯度. 开发的方法证明了利用农业残留物用于可持续平台化工生产的技术经济可行性.
科学领域:
- 生物技术和生物工程 生物技术和生物工程
- 可持续化学 可持续化学
背景情况:
- 对于化石化学品的可持续替代品的日益增长的需求推动了人们对可再生平台化学品 (如酸) 的兴趣.
- 目前的生产方法受到高成本的阻碍,特别是基质成本,以及从糖糖蜜等复杂原料中下游加工酸的挑战.
- 糖蜜发酵中的高度,抑制剂和色素使微生物的生产和分离复杂化.
研究的目的:
- 开发一种综合且技术经济上可行的工艺,用于从未经过处理的甜菜糖蜜中生产酸.
- 为了优化发酵生产和下游加工酸和酸.
- 为了证明使用农业残留物用于可持续平台化学制造的可行性.
主要方法:
- 研究了Ustilago trichophora在各种批量配置 (批量,料批量,脉冲批量) 的发酵酸生产,在摇瓶和试验秤 (150升).
- 采用基于膜的细胞保留用于重复脉冲批次发酵,实现高标位和产量.
- 利用活性炭进行两阶段的产品捕获,溶剂更换和脱色,然后进行结晶以进行下游净化.
主要成果:
- 通过重复脉冲批发酵和细胞保留,生产了15.7公斤的酸,度为108g/L,产量为0.50g/g,时空产量为0.66g/L/h.
- 检测到的副产品是酸,度高达22.9g/L.
- 开发了一个Aspen Plus模型,估计整体工艺产量为0.43g酸 (98%纯度) 和0.10g酸/克糖等价,生产成本与市场价格相匹配.
结论:
- 开发的从未经过处理的糖蜜中生产酸的整体方法解决了关键的挑战,在显著的规模上证明了技术经济可行性.
- 这一过程为利用农业残留物作为平台化工生产的成本效益高的原料提供了可行的途径.
- 该研究强调了从可再生资源中制造有机酸的可持续和竞争力制造的潜力.
关键词:
乌斯蒂拉戈三角 (Ustilago trichophora) 是一种三角.吸附方式 吸附方式 吸附方式生物经济是生物经济.脱色的方法是脱色.下游加工是下游加工.联邦储备局批次批量黄酸是什么 黄酸是什么 黄酸是什么基于膜的细胞保留糖蜜糖是什么意思 糖蜜糖是什么意思重复的脉冲批次重复的脉冲批次更多相关视频
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