健康生活方式得分与成年人甲状腺功能生物标志物之间的关联:横截面分析
Xueqin Cheng1, Xi Chen2, Lijun Yan3
1Department of Thyroid and Breast Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China.
The British journal of nutrition
|February 4, 2026
概括
通过健康生活方式得分 (HLS) 衡量更健康的生活方式,与美国成年人自由甲状腺素 (FT4) 和总甲状腺素 (TT4) 的较低水平有关. 这表明可修改的行为可能会影响甲状腺功能.
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生和流行病学
- 营养科学 营养科学
背景情况:
- 甲状腺功能对于新陈代谢调节至关重要.
- 生活方式因素越来越多地被认为对内分泌健康的影响.
- 了解生活方式和甲状腺生物标志物之间的相互作用对于预防性健康策略很重要.
研究的目的:
- 调查美国成年人代表样本中复合健康生活方式评分 (HLS) 和甲状腺功能生物标志物之间的关联.
- 为了确定是否坚持健康的生活方式影响关键的甲状腺激素和抗体.
主要方法:
- 从NHANES 2007-2012年数据对5,693名美国成年人的横截面分析.
- 基于六个因素创建了健康生活方式评分 (HLS):饮食,体育活动,睡眠,酒精摄入量,吸烟状况和BMI.
- 使用多变量线性回归模型来评估HLS和血清甲状腺生物标志物 (TSH,FT4,TT4,FT3,TT3,Tg,TPOAb,TgAb) 之间的关系,并对共变量进行调整.
主要成果:
- 较高的健康生活方式得分 (HLS) 与较低的血清度的自由甲状腺素 (FT4) 和总甲状腺素 (TT4) 有显著的关联.
- 具体来说,每增加一个点的HLS与FT4和TT4水平的下降相关.
- 与HLS (0-1) 最低的参与者相比,具有最高HLS (4-6) 的参与者表现出明显较低的FT4和TT4.
- 在对多次比较进行调整后,对于其他甲状腺标志物 (TSH,FT3,TT3,Tg,TPOAb,TgAb) 没有发现显著的关联.
结论:
- 更健康的生活方式,以积极的可修改行为为特征,与美国成年人循环FT4和TT4水平相反相关.
- 这些发现表明,生活方式选择与甲状腺激素调节之间存在潜在联系.
- 需要进一步的研究来探索这种关联及其临床影响背后的机制.
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