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在艾滋病毒感染者中,QuantiFERON-TB金+:在低结核病负担的环境中,独立于CD4+T细胞计数
Erika Asperges1,2, Roberto Gulminetti2, Laura Maiocchi2
1Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, University of Pavia, Pavia, Italy.
HIV research & clinical practice
|February 4, 2026
概括
检测QuantiFERON-TB Gold-Plus (QFT-GP) 测试显示,在感染艾滋病毒的人群中,无论CD4+T细胞数量如何,不确定的结果很低. 这有助于改善这一弱势群体的结核病查.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 查对携带艾滋病毒的人来说至关重要.
- 由于依赖CD4+T细胞反应,QuantiFERON-TB金管测定可以产生不确定的结果.
- 更新的QuantiFERON-TB Gold-Plus (QFT-GP) 试验包括CD8+T细胞反应,可能减少不确定的结果.
研究的目的:
- 评估QFT-GP试验在大量艾滋病毒感染者群体中的表现.
- 评估该人群中不确定的QFT-GP结果的频率,特别是在低结核病流行环境中.
主要方法:
- 对艾滋病毒感染者的QFT-GP测试结果的回顾性评估.
- 收集人口统计数据,CD4+和CD8+T细胞计数 (近期和当前),以及结核病史.
- QFT-GP结果与CD4+T细胞计数之间的相关性分析.
主要成果:
- 总共有695人被纳入该研究.
- 只有1.2%的QFT-GP测试是不确定的.
- 不确定结果与测试时的CD4+或CD8+T细胞计数或最低值之间没有发现关联.
结论:
- QFT-GP测定表明,艾滋病毒感染者中不确定的结果的频率很低.
- 这一发现甚至适用于CD4+ T细胞计数较低的个体.
- 对于艾滋病毒感染者来说,QFT-GP提供了一个更可靠的结核病查选择.
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