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Updated: Feb 5, 2026

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在两个尿道总蛋白质检测方法中的二甲基酸干扰
Zheng Mingqi1,2, Ma Xiaoli1, Yu Songlin1
1Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Journal of clinical laboratory analysis
|February 4, 2026
概括
二甲酸不会干扰尿道总蛋白质检测的红色酸-红色酸方法. 然而,它显著干扰甲化方法,影响基于药物和蛋白质度的结果.
科学领域:
- 临床化学 临床化学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 尿道总蛋白质测量对于诊断和监测脏疾病至关重要.
- 二甲酸是一种可能存在于尿样中的药物.
- 药物在诊断试验中的潜在干扰需要仔细评估.
研究的目的:
- 调查二甲酸盐在两种常见的尿道总蛋白质检测方法中的干扰.
- 量化不同二甲酸度引起的干扰的程度和性质.
主要方法:
- 采集了24小时和点滴尿样,来自接受二甲酸盐治疗的患者.
- 使用液体染色学-并联质谱法量化药物度.
- 通过对差测试和剂量效应实验评估干扰.
主要成果:
- 二甲酸并没有显著干扰红色酸的pyrogallol方法.
- 在乙化方法中观察到显著干扰,显示出"J形"效应.
- 干扰因二甲酸和尿蛋白度而异,偏差范围从-12.1%到+286.4%.
结论:
- 铁醇红基酸盐方法可靠检测尿道总蛋白质在服用二酸盐的患者.
- 甲方法容易受到二酸盐的干扰,影响准确性.
- 在使用乙法时,建议在尿液采集前1-2天停止服用二酸盐.
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