胰腺神经内分泌瘤发生率趋势的决定因素
Giuseppe Lamberti1, Elisa Andrini1, Adriana Di Odoardo1
1Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Journal of neuroendocrinology
|February 4, 2026
概括
胰腺神经内分泌瘤 (NENs) 的发生率显著增加,这可能是由于检测的改善而不是疾病的真正增加. 这一趋势在获得更好的医疗保健的人群中更为明显.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 胰腺神经内分泌瘤 (NENs) 的发病率正在上升,但原因尚不清楚.
- 区分真正的疾病增加和改进的检测对于理解NEN趋势至关重要.
研究的目的:
- 检查从1975年到2021年胰腺NEN发病率的时间趋势.
- 评估观察到的发病率变化是否反映了更好的检测或疾病发生率的真正增加.
- 根据影响医疗保健获取的人口和社会经济因素分析发病率趋势.
主要方法:
- 基于人口的回顾性研究,使用监测,流行病学和最终结果 (SEER) 计划数据 (1975-2021).
- 确定了16253例胰腺NEN病例.
- 分析了因收入,居住环境,种族,瘤大小,等级和位置而分层的发病趋势.
主要成果:
- 在1975年至2021年期间,胰腺NEN发病率增加了7.75倍 (每10万人中0.21至1.58).
- 诊断时的中位数瘤大小显著下降.
- 在男性,白人,高收入群体和城市人口中,发病率增加得更快,这表明检测有所改善.
结论:
- 胰腺NEN的发病率上升很可能是由于检测的改善,特别是在获得更好的医疗保健的人群中.
- 研究结果表明,增强的诊断能力,而不是真正的疾病增加,解释了观察到的流行病学趋势.
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