1型糖尿病父母怀孕结果的时间趋势:全国性的基于登记的研究
Tina Wullum Gundersen1, Sine Knorr2, Lene Ringholm3,4
1Steno Diabetes Center Zealand, Zealand University Hospital, Nykoebing Falster, Denmark.
BJOG : an international journal of obstetrics and gynaecology
|February 4, 2026
概括
孕妇患有1型糖尿病的孕妇仍然有明显更高的不良后果风险,尽管25年来情况有所改善. 与一般人群相比,父亲1型糖尿病的风险没有增加.
科学领域:
- 生殖医学和内分泌学.
- 周产期流行病学.
- 公共卫生. 公共卫生.
背景情况:
- 父母患有1型糖尿病会影响怀孕的结果.
- 了解时间趋势对于改善护理至关重要.
研究的目的:
- 为了检查25年来1型糖尿病的母亲和父亲怀孕结果的变化.
- 将这些结果与一般人群进行比较.
主要方法:
- 一项基于丹麦登记的研究分析了1997年至2021年期间的1,551,893例怀孕情况.
- 后勤回归模型评估了诸如高血压疾病,剖腹产,早产和妊娠年龄大 (LGA) 等结果.
主要成果:
- 孕妇1型糖尿病怀孕显示,随着时间的推移,早产和极端LGA的几率下降,但风险仍然大幅增加.
- 父亲1型糖尿病怀孕的结果与一般人群的结果相似.
- 在研究期间,母亲和父亲糖尿病的患病率增加.
结论:
- 尽管情况有所改善,但母亲的1型糖尿病显著增加了不良怀孕风险.
- 有效的孕产妇糖尿病管理似乎比孕产妇遗传因素对妊娠结果更为关键.
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